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For a time, she accompanied them through the ship to a possible area of safety after encountering the "small infection" that plagued the ship and it's crew. Nicole oversaw the health and status of the survivors during a routine quarantine check.

Nicole Brennan - The Senior Medical Officer aboard the USG Ishimura, Dead Space: Extraction saw Nicole in an active role of duty before her death.

Warren took a seemingly neutral position on the issue of Unitology and is quick to defend them from accusation.

Warren Eckhardt - A CEC executive aboard the USG Ishimura, Warren often provided the group with access to rooms and areas blocked to those without executive clearance or permission.

Alongside Nathan, the sergeant protected Lexine and Warren Eckhardt from the hideous creatures that inhabited the Ishimura.

Gabe Weller - A security officer aboard the USG Ishimura, Gabe and his team are assigned to a body retrieval mission on Aegis VII when the outbreak occurred on the colony.

He took on the responsibility of protecting Lexine after insisting that she should accompany him and Gabe to safety.

Nathan McNeill - The main character and protagonist of the game, Nathan is a P-Sec detective overseeing the investigation of the murders committed by Sam Caldwell.

Lexine had an apparent immunity to the effects of the Red Marker and experienced odd headaches and bouts of nausea on the Ishimura. She accompanied the survivors to the USG Ishimura in the hopes of finding refuge from the terrors spreading through her home.

Lexine Murdoch - The girlfriend of Sam Caldwell, Lexine is a surveyor on Aegis VII present during the second Necromorph outbreak on the colonized planet.

Throughout the first chapter, the player controlled Sam as he tried to reestablish the power and life support to the colony during the unexplained murders of his teammates and the miners down in the Megavents. Sam Caldwell - A playable character for the first chapter, Sam is an engineer on Aegis VII tasked with removing the Red Marker from its pedestal.